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In preclinical work, MOTS-c is described as interfering with the folate cycle, leading to a build-up of AICAR (an AMP analog) that switches on AMPK [1] [2]

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Impaired renal function , an indicator of chronic kidney disease, also leads to higher serum MMA concen­trations even from the early stages of renal impairment, as shown in (Figure 22b.6)