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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig
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The Endocrine Society's Clinical Practice Guideline on male hypogonadism states: "We recommend testosterone therapy for men with symptomatic hypogonadism to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, and bone mineral density." Bhasin et al., J Clin Endocrinol Metab, 2018
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