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Therefore, successful translation will depend on advances in targeted CNS delivery systems and a thorough understanding of the temporal dynamics of microglial activation in tinnitus pathogenesis
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α-TTP itself is not secreted from the hepatocyte but remains in the cytosol, while α-tocopherol is transferred to an external lipoprotein acceptor, such as nascent high-density or very low-density lipoproteins (HDL or VLDL)
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